SnapShot: Cellular Senescence in Pathophysiology
نویسندگان
چکیده
منابع مشابه
SnapShot: Cellular Bodies
Cajal Body 0–6 0.1–2.0 µm; round Coilin Involved in snRNP and snoRNP biogenesis and posttranscriptional modification of newly assembled spliceosomal snRNAs. Clastosome 0–3 0.2–1.2 µm; irregular 20S core catalytic component of proteasome Contains ubiquitin conjugates, the proteolytically active 20S core and 19S regulatory complexes of the 26S proteasome, and protein substrates of the proteasome.
متن کاملIn Vitro Evaluation of Protective Effect of Rutin on Acrylamide-Induced Cellular Senescence in NIH3T3 Cells
Background: Aging is one of the important factors in the development of age-related diseases. Acrylamide can be produced during carbohydrate-rich foods prepared at high temperatures. Recently, studies showed that acrylamide can induce cellular senescence. On the other hand, Rutin as a natural flavonoid, has a potent antioxidant activity. Objective: This study aims to evaluate the ptotective ef...
متن کاملp16INK4a in cellular senescence
senescence is the activation of the INK4/ARF locus, which is epigenetically regulated and under tight control of the Polycomb group (PcG) Trithorax group (TrxG) proteins [1]. In proliferating cells, the locus is silenced by Polycomb repressive complexes (PRCs), and the chromatin is enriched in H3K27me3 [2]. Upon senescence triggers, PRCs are displaced and the repressive H3K27me3 mark is removed...
متن کاملCellular senescence in osteoarthritis pathology
Cellular senescence is a state of stable proliferation arrest of cells. The senescence pathway has many beneficial effects and is seen to be activated in damaged/stressed cells, as well as during embryonic development and wound healing. However, the persistence and accumulation of senescent cells in various tissues can also impair function and have been implicated in the pathogenesis of many ag...
متن کاملCellular senescence in aging primates.
The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2017
ISSN: 0092-8674
DOI: 10.1016/j.cell.2017.08.025